The Science behind Epitalon, the Miracle Anti-Aging Peptide


Known as the synthetic version of the tetrapeptide epithalamin, which naturally occurs in the pineal gland in our body, Epitalon (also known as Epithalon or Epithalone) was first discovered in the late 1980’s by Prof. Vladimir Khavinson from The Sankt Petersburg University, Russia. The life extension and anti-aging properties of the synthetic tetrapeptide Epitalon (telomerase activator) are remarkable.


As the most prominent tasks of the pineal gland are to maintain different kind of processes in our body, such as to normalize the activity of anterior pituitary and to maintain the levels of calcium, gonadotropins, and melatonin, its activity is highly regulated by a series of feedback mechanisms. Epithalamin acts as an antioxidant and increases the resistance to stress and lowers the levels of corticosteroids.

Over the years, Prof. Vladimir Khavinson has conducted extensive studies on mice and humans and has come across interesting conclusions, supporting evidence such as anti-aging, telomerase activation and elongation of telomeres due to Epitalon action.

1.1. Life extension by elongation of telomeres and telomerase activation

Gene expression is different in young, middle-aged, and old individuals. The body times the life cycle using gene expression. In childhood, genes dictate the body to grow, in the middle age they maintain the body strong and healthy, and in the old age they dictate the body to stop releasing vital hormones, thus slowing down life processes and destroying the body.

pineal gland

Telomerase (a.k.a. telomere terminal transferase) is the enzyme capable to elongating telomeres in human bodies while protecting the DNA from the damage caused by aging. When cells multiply, they are set a predefined number of cycles they can perform the divisions due to the permanent curtailment of telomeres. In Mr. Khavinson’s studies, Epitalon treated cells made a total of forty-four passages (ten extra divisions compared to normal cells). Thus, the studies support the evidence that Epitalon prolongs the life of cells due to overcoming of the Heyflick division limit. (Reference: V. Khavinson et al. in Bulletin of Experimental Biology and Medicine. June 2003, PMID:12937682).telomeres-immortality-epitalon

1.2 Epitalon and the anti-aging properties

Similar to thymalin (found to stimulate gland thymus re-growth and to rejuvenate the immune function), epithalamin is a sequence of four amino acids. The structure of Epitalon is: Ala-Glu-Asp-Gly. Epitalon decreases the age-related changes in the immune and the neuroendocrine systems, reducing the incidence of chronic diseases and infections. Similar effects have been observed in patients treated with thymalin but at lower extent. (Reference: V. Khavinson et al. in Bulletin of Experimental Biology and Medicine. March 2002, PMID:12577695).

Twelve months studies conducted by Prof. Vladimir Khavinson in patients showing advanced level of accelerated aging demonstrated a normalizing effect on metabolism and the improvement of overall health condition. Following ten days of treatment, elevated cholesterol, uric acid, and alkaline phosphatase levels have returned to normal and maintained stable for several months.

1.3 Epitalon effects in humans

Clinical studies have shown a plethora of positive effects in middle-aged and old patients. According to the studies carried out by the Russian scientist and his team, the most conclusive effects of Epitalon in humans are:

  1. The elongation of telomeres, thus the protection against cancer and other age-related diseases.
  2. Regulation of the nouroendocrinous system.
  3. Normalization of the gonadotropic hormones (LH, FSH, PRL)
  4. Improvement of peripheral hemodynamics
  5. Normalization of T-cells immunology.
  6. Regularization of cholesterol and uric acid levels
  7. Tumor prevention (inhibition of cancer cells due to protective effect of elongated telomeres)

1.4 Epitalon side effects

Studies carried out by Prof. Vladimir Khavinson have reported no side effects associated with the administration of Epitalon. Epitalon users on various Internet forums have also reported no side effects.

1.5 Epitalon dosage

Due to the short length of the amino-acidic chain, Epitalon is administrated orally, nasal spray drops (same as melanotan) or injectable (by far the most effective method) in 10 – 20 days-in-row cycles.

  • Oral administration: 2 – 8 mg/day, 2 – 3 servings per day
  • Nasal administration: 1 – 5 mg/day, 3 servings per day
  • Injectable administration: 0.5 – 3 mg/day, 1 – 2 injections per day (intramuscularly or subcutaneously)

1.6 Reconstitution and storage

Epitalon comes in a lyophilized powder. It is recommended to inject 1 – 2ml of sterile or bacteriostatic water into the vial and mix gently.

Although stable at room temperature for ninety days in lyophilized form, once reconstituted, the solution should be kept refrigerated between 2 – 8 degrees Celsius for maximum 20 days.


  1. V. Khavinson et all. in Bulletin of Experimental Biology and Medicine. June 2003, PMID:12937682
  2. V. Khavinson et all. in Bulletin of Experimental Biology and Medicine. March 2002, PMID:12577695
  3. Modulating Aging and Longevity (p. 288-290) by S.I. Rattan:
  4. NEL.EDU – Neuroendocrinology Letters:


  1. I dont agree with your Epitalon dosage recommendations and would like to know where you obtained these figures from especially the oral dosage figures.

    • Andrei D. (Kidål) says:

      if you say it is wrong, come up with dosage ideas 🙂

      • It wasnt meant to be confrontational.

        I have not seen any research that points to such high dosages anywhere and would like to know how you arrived at these figures.

        Nobody I have seen recommends such high doses particularly as oral and none of the products anywhere in the world including those of prof Khavinson suggest such figures. Maybe you have got your mg mixed up with mcg?

        Only other problem is the reference to the risk of cancer in the video. Exercise can increase telomerase but that doesn’t mean exercise causes cancer or that people should give up exercise!.

        In the view of most experts today that view expressed is well off the mark and contradicts the other positive points in your article.

        I like the basis of the article and the title. Pity about the points I have mentioned!

        • Andrei D. (Kidål) says:

          The author has made the corrections so the information is now accurate.

          With regards to the video, it does not say that the Epitalon peptide is responsible for cancers but in general, more replications mean more chances of mutations in humans. However, it is well known that, compared to the action of IGF-1 for example, Epithalon does not have such properties of directly influencing and growing of cancer cells.

  2. Charles V Grashow says:

    How long should the off cycle period be?

  3. can it be use topically in say haluronic acid solution or only for internall use

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