Biostatistics
Randomization in Clinical Trials
Theory and Practice
Author:
Rosenberger, William F.; John M. Lachin
Isbn 13:
9780471236269
ISBN: 0471236268
Pub Date:
Jul 1, 2002
Publisher:
Wiley
Shipping Weight: 1.16 pounds
Status:
ON DEMAND PRINT
Quantum Price: $113.85
Quantity in Basket: None
Winner of the 2002 Associaton of American Publishers Professional/Scholarly Publishing Division Award The role of randomization techniques in clinical trials has become increasingly important. This comprehensive guide combines both the applied aspects of randomization in clinical trials with a probabilistic treatment of properties of randomization. Taking an unabashedly non-Bayesian and nonparametric approach to inference, the book focuses on the linear rank test under a randomization model, with added discussion on likelihood-based inference as it relates to sufficiency and ancillarity. Developments in stochastic processes and applied probability are also given where appropriate. Intuition is stressed over mathematics, but not without a clear development of the latter in the context of the former. Providing a consolidated review of the field, the book includes relevant and practical discussions of: *The benefits of randomization in terms of reduction of bias *Randomization as a basis for inference *Covariate-adaptive and response-adaptive randomization *Current philosophies, controversies, and new developments With ample problem sets, theoretical exercises, and short computer simulations using SAS, Randomization in Clinical Trials: Theory and Practice is equally useful as a standard textbook in biostatistics graduate programs as well as a reliable reference for biostatisticians in practice.
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